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Wang, Y. H.; Turdu, G.; Zhao, X. M.; Hu, A. L.; Yang, Z.; Dongmulati, N.; Arken, A.; Kelaimu, R.; Wali, A.; Ali, Y.; Gao, Y. H.; Mavlonov, G. T.; Yili, A.; Aisa, H. A.
Chemistry of natural compounds, 01/2024, Letnik: 60, Številka: 1Journal Article
A glycoprotein inhibiting the growth of colon cancer cells was isolated from sheep intestinal mucous membrane. The glycoprotein, designated IGP, was purified by a combination of ion-exchange chromatography over DEAE-650M and gel-filtration over HW-55F. Purified IGP had a molecular mass of ~60 kDa and consisted of 68.72 ± 2.10% protein and 32.09 ± 1.52% carbohydrates. The monosaccharide composition of the carbohydrate part consisted of glucose (31.28% of the total carbohydrate content), glucosamine (22.28%) and N -acetylgalactosamine (19.38%), mannose (11.14%), fucose (11.28%), and rhamnose (4.64%). The amino-acid composition of IGP was also determined.
