Upon referral, the patient presented a thick grayish scaly rash with an inflammatory background that was more pronounced on the lower limbs (legs, thighs, Figures 1A and 1B) but affected also the upper limbs (Figure 1C) and shoulders, the lower abdomen and the buttocks. Histology of a skin biopsy from the thigh showed acanthosis and hyperkeratosis of the epidermis and some perivascular lymphocytes, but no eosinophils in the dermis (Figure 1D). Because of its efficacy on CML and the lack of alternative, ponatinib was maintained. CONFLICT OF INTEREST The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research reported.