Display omitted •Ti/SrxLa1-xMnyCo1-yO3-δ anode is prepared by doping Sr and Mn into LaCoO3 matrix.•Sr and Mn are doped into LaCoO3 to form oxygen vacancies and improve conductivity.•Oxygen vacancies can inhibit the recombination of e−-h+ pairs to produce more OH.•Ammonia nitrogen and organics can be degraded effectively under optimum condition.•The anode shows attractive reusability and stability with low energy consumption. To obtain a kind of highly active, robust, inexpensive anode for electrocatalytic oxidizing wastewater, perovskites SrxLa1-xMnyCo1-yO3-δ (SLMCOxy) were prepared by doping Mn at B-Site and Sr at A-Site into the LaCoO3 matrix to form oxygen vacancies, inducing more production of reactive oxidized substance. Then the perovskites mixed with binder and conductive agent were coated on titanium plate as alternative anodes Ti/SLMCOxy, which were applied for cleaning simulated wastewater composed of 200 mg L−1 ammonium nitrogen (AN) and 20 mg L−1 methyl orange (MO) to confirm the optimum doping amount of Sr and Mn and operation conditions like temperature, current density, pH and the concentration of chloride. The highest removal ratio up to 98.23% for AN, 99.61% for MO, 88.16% for COD and current efficiency up to 86.47% were achieved respectively with the contribution of OH, O2− and active chlorine, and the removal ratio of AN and MO can keep above 95% after 5-time’s reusing the anode. Moreover, the anode performed good degradation effect for landfill leachate with 96.12% of AN and 85.43% of COD removed at energy consumption of 26.88 kWh (Kg COD)−1. Therefore, this original anode Ti/SLMCOxy would be a promising candidate for effective organic wastewater treatment.