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Hu, Xinyue; Gong, Tingting; Yao, Zhili; Wang, Zhenlian; Cheng, Jiang
Tetrahedron letters, 02/2024, Letnik: 136Journal Article
Display omitted We reported the base-promoted cyclization of N-Boc arylimidrazone toward 1,2-dihydro 3H-1,2,4-triazol-3-one. This procedure tolerated methyl, methoxy, chloro, bromo, fluoro, cyano, methylcarbonyl groups well. Thus, it represents a facile and high efficient pathway leading to 1,2-dihydro 3H-1,2,4-triazol-3-one. Mechanism study revealed this procedure proceeded with the intramolecular nucleophilic cyclization rather than N-isocyanate intermediate.
