Rain properties vary spatially and temporally for several reasons. In particular, rain types (convective and stratiform) affect the rain drop size distribution (DSD). It has also been established that local weather conditions are influenced by large-scale circulations. However, the effect of these circulations on rain microstructures has not been sufficiently addressed. Based on DSD measurements from 16 disdrometers located in Lausanne, Switzerland, we present evidence that rain DSD differs among general weather patterns (GWLs). GWLs were successfully linked to significant variations in the rain microstructure characterized by the most important rain properties: rain intensity (R), mass weighted rain drop diameter (Dm), and rain drop concentration (N), as well as Z = ARb parameters. Our results highlight the potential to improve radar-based estimations of rain intensity, which is crucial for several hydrological and environmental applications.