Persistence was recently identified to have three dimensions: persistence despite difficulties (PDD), persistence despite fear (PDF), and inappropriate persistence (IP). To promote the study of multidimensional persistence, we integrate the approach/avoidance framework with PDD, PDF, and IP. We assess the relations of these three dimensions with both known and novel outcomes, and we also test whether approach and avoidance motivations mediate these effects. From a time-separated study, our results show that PDD and PDF produce beneficial work and well-being outcomes, whereas IP produces detrimental work and well-being outcomes. Approach motivations also mediated the relations of PDD with outcomes, whereas avoidance motivations mediated the relations of PDF and IP with outcomes. These results support that the approach/avoidance framework is a viable perspective to understand the outcomes of persistence. We recommended that future researchers should assess the broader proposals of the approach/avoidance framework regarding persistence, and we also suggest that future researchers can now link persistence with other outcomes previously associated with approach and avoidance motivations.