Emerging interdisciplinary science efforts are providing new understanding of the interdependence of food, energy, and water (FEW) systems. These science advances, in turn, provide critical information for coordinated management to improve the affordability, reliability, and environmental sustainability of FEW systems. Here we describe the current state of the FEW nexus and approaches to managing resource conflicts through reducing demand and increasing supplies, storage, and transport. Despite significant advances within the past decade, there are still many challenges for the scientific community. Key challenges are the need for interdisciplinary science related to the FEW nexus; ground‐based monitoring and modeling at local‐to‐regional scales; incorporating human and institutional behavior in models; partnerships among universities, industry, and government to develop policy relevant data; and systems modeling to evaluate trade‐offs associated with FEW decisions. Key Points Food consumes 90% of global freshwater but 25–30% is lost or wasted; therefore, saving food saves embodied water and energy Resource scarcity can be managed by reducing demands, increasing supplies, storage, or transport Advances in remote sensing and modeling provide tools to develop adaptive strategies to manage the FEW nexus