The vulnerability analysis of cladding usually reflects the performance levels of roof systems under wind uplift failure. But the damage area of roof system under wind uplift failure is often large, and this causes difficulty in post-disaster reconstruction. In this study, the vulnerability analysis of a roof system was conducted considering the multistage performance levels during the wind uplift failure process of the roof system. First, based on a study on the wind uplift failure mechanism of the roof system, the failure process was divided into four stages according to the deformation of the roof system components and the change in structural responses. Second, the classification criteria and restoration measures corresponding to three-stage performance levels (moderate damage, severe damage, and failure) of the roof system were proposed based on the results of 50 numerical cases. Third, the damage parameter β was defined as a unified index to quantify the three-stage performance levels. The quantitative results for the numerical cases were consistent, and the damage parameter β values were 0.4, 0.73, and 1.0 respectively. Finally, the uncertainty of material properties was considered, and the Latin hypercube sampling was performed to generate structural samples. On this basis, 7000 load–structure samples were analyzed using numerical methods, and the vulnerability curves of the roof system were obtained by fitting the numerical calculations result using the least-squares method. The vulnerability curves can be used as a reference for selecting roof system models and adopting restoration measures after a disaster based on the engineering requirements. •The three-stage performance levels of the roof system are defined based on the wind uplift failure process.•The damage parameter β is defined as a unified index to quantify the three-stage performance levels.•Considering the three-stage performance levels of roof system in the process of usage, the wind vulnerability analysis is carried out.•Comparing the vulnerability of different types of roof systems, so as to serve the engineering.