Display omitted Asphaltene is the most complex component of crude oil, consisting of various molecular structures, e.g., different molecular weights and number of rings per fused-ring system (or aromatic moiety). Asphaltene has been reported to cause complicated problems during production and transportation. Asphaltene is also asociated with severe detrimental effects to the environment. Because of its problematic nature, asphaltene has been treated as a waste material for many years. Recently, advanced analytical techniques have been applied to elucidate the chemo-physical structure of asphaltene. Progress in research has facilitated the application of asphaltene in various fields. Herein, we provide a comprehensive review of advanced applications of asphaltene in different industries. It is shown that asphaltene has been successfully used in various fields (e.g., polymer industry, nanomaterial synthesis and surface modification, electronics, emulsions, and interfaces). The novel applications in each field is also discussed. This work provides insight to create value-added products from asphaltene and helps researchers to further contribute to these efforts and bring to new markets this precious waste material.