The interest in the benefits of caffeine in combat sports has grown exponentially in the last few years, evidenced by the significant rise of post-competition urine caffeine concentration. We conduct a systematic review and meta-analysis on the effects of caffeine on different performance variables in combat sports athletes. In total, we included 25 studies. All studies included had blinded, and cross-over experimental designs, and we conducted a risk of bias analysis. For nonspecific outcomes, there was an ergogenic effect of caffeine on vertical jump height (SMD: 0.38; 95% CI: 0.04, 0.71) and reaction time (SMD: −0.98, 95% CI: −1.46,−0.50). For outcomes specific to combat sports, there was an increase in the number of throws with caffeine in the Special Judo Fitness Test (SMD: 0.62; 95% CI: 0.14, 1.09). Caffeine ingestion increased the number of offensive actions during combats (SMD: 0.40; 95% CI: 0.06, 0.74). Caffeine ingestion increased the duration of offensive actions during combat (SMD: 0.58; 95% CI: 0.21, 0.96). Finally, caffeine ingestion increased blood lactate concentration after bout 1 (SMD: 1.35) bout 2 (SMD: 1.43) and bout 3 (SMD: 1.98). Overall, athletes competing in combat sports may consider supplementing with caffeine for an acute increase in exercise performance.