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Borna, Simon; Drobek, Ales; Kralova, Jarmila; Glatzova, Daniela; Splichalova, Iva; Fabisik, Matej; Pokorna, Jana; Skopcova, Tereza; Angelisova, Pavla; Kanderova, Veronika; Starkova, Julia; Stanek, Petr; Matveichuk, Orest V.; Pavliuchenko, Nataliia; Kwiatkowska, Katarzyna; Protty, Majd B.; Tomlinson, Michael G.; Alberich‐Jorda, Meritxell; Korinek, Vladimir; Brdicka, Tomas
Journal of Cellular and Molecular Medicine, January 2020, Letnik: 24, Številka: 2Journal Article
WW domain binding protein 1‐like (WBP1L), also known as outcome predictor of acute leukaemia 1 (OPAL1), is a transmembrane adaptor protein, expression of which correlates with ETV6‐RUNX1 (t(12;21)(p13;q22)) translocation and favourable prognosis in childhood leukaemia. It has a broad expression pattern in haematopoietic and in non‐haematopoietic cells. However, its physiological function has been unknown. Here, we show that WBP1L negatively regulates signalling through a critical chemokine receptor CXCR4 in multiple leucocyte subsets and cell lines. We also show that WBP1L interacts with NEDD4‐family ubiquitin ligases and regulates CXCR4 ubiquitination and expression. Moreover, analysis of Wbp1l‐deficient mice revealed alterations in B cell development and enhanced efficiency of bone marrow cell transplantation. Collectively, our data show that WBP1L is a novel regulator of CXCR4 signalling and haematopoiesis.
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Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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