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Teeguarden, Justin G.; Hanson-Drury, Sesha
Food and chemical toxicology, 12/2013, Letnik: 62Journal Article
Display omitted •Human exposure to the estrogenic food contaminant bisphenol A is low, but widespread.•An accumulation of published “low dose” BPA toxicity studies has been used to imply risk to exposed humans.•A review of “low-dose” BPA studies revealed that a minority of studies were conducted in the range of human exposures.•“Low-dose” is non-specific, comprising to exposures ranging over 8–12 orders of magnitude.•Human exposure, not subjective terms such as “low-dose,” should be the standard for reporting toxicity data. Human exposure to the chemical Bisphenol A is almost ubiquitous in surveyed industrialized societies. Structural features similar to estrogen confer the ability of Bisphenol A (BPA) to bind estrogen receptors, giving BPA membership in the group of environmental pollutants called endocrine disruptors. References by scientists, the media, political entities, and non-governmental organizations to many toxicity studies as “low dose” has led to the belief that exposure levels in these studies are similar to humans, implying that BPA is toxic to humans at current exposures. Through systematic, objective comparison of our current, and a previous compilation of the “low-dose” literature to multiple estimates of human external and internal exposure levels, we found that the “low-dose” moniker describes exposures covering 8–12 orders of magnitude, the majority (91–99% of exposures) being greater than the upper bound of human exposure in the general infant, child and adult U.S. Population. “low dose” is therefore a descriptor without specific meaning regarding human exposure. Where human exposure data are available, for BPA and other environmental chemicals, reference to toxicity study exposures by direct comparison to human exposure would be more informative, more objective, and less susceptible to misunderstanding.
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