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Recenzirano
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MacDonagh, Lauren; Gray, Steven G; Finn, Stephen P; Cuffe, Sinead; O’Byrne, Kenneth J; Barr, Martin P
Cancer treatment reviews, 02/2015, Letnik: 41, Številka: 2Journal Article
Highlights • MicroRNAs (miRNAs) are small, non-coding RNAs that post-transcriptionally control the translation and stability of mRNAs. • It has been predicted that miRNAs could potentially regulate more than 60% of human genes. • Cancer treatment resistance, either de novo or acquired, remains a major challenge in the management of cancer patients. • A compelling body of evidence points to the direct involvement of miRNAs in resistance to lung cancer treatments. • MicroRNAs harbour potential translational value, however their use as theranostics requires further validation.
