E-viri
Recenzirano
Odprti dostop
-
Cao, Yue; Haring, Catherine T; Brummel, Collin; Bhambhani, Chandan; Aryal, Madhava; Lee, Choonik; Heft Neal, Molly; Bhangale, Apurva; Gu, Wenjin; Casper, Keith; Malloy, Kelly; Sun, Yilun; Shuman, Andrew; Prince, Mark E; Spector, Matthew E; Chinn, Steven; Shah, Jennifer; Schonewolf, Caitlin; McHugh, Jonathan B; Mills, Ryan E; Tewari, Muneesh; Worden, Francis P; Swiecicki, Paul L; Mierzwa, Michelle; Brenner, J Chad
Clinical cancer research, 01/2022, Letnik: 28, Številka: 2Journal Article
In locally advanced p16+ oropharyngeal squamous cell carcinoma (OPSCC), (i) to investigate kinetics of human papillomavirus (HPV) circulating tumor DNA (ctDNA) and association with tumor progression after chemoradiation, and (ii) to compare the predictive value of ctDNA to imaging biomarkers of MRI and FDG-PET. Serial blood samples were collected from patients with AJCC8 stage III OPSCC ( = 34) enrolled on a randomized trial: pretreatment; during chemoradiation at weeks 2, 4, and 7; and posttreatment. All patients also had dynamic-contrast-enhanced and diffusion-weighted MRI, as well as FDG-PET scans pre-chemoradiation and week 2 during chemoradiation. ctDNA values were analyzed for prediction of freedom from progression (FFP), and correlations with aggressive tumor subvolumes with low blood volume (TV ) and low apparent diffusion coefficient (TV ), and metabolic tumor volume (MTV) using Cox proportional hazards model and Spearman rank correlation. Low pretreatment ctDNA and an early increase in ctDNA at week 2 compared with baseline were significantly associated with superior FFP ( < 0.02 and < 0.05, respectively). At week 4 or 7, neither ctDNA counts nor clearance were significantly predictive of progression ( = 0.8). Pretreatment ctDNA values were significantly correlated with nodal TV , TV , and MTV pre-chemoradiation ( < 0.03), while the ctDNA values at week 2 were correlated with these imaging metrics in primary tumor. Multivariate analysis showed that ctDNA and the imaging metrics performed comparably to predict FFP. Early ctDNA kinetics during definitive chemoradiation may predict therapy response in stage III OPSCC.
Avtor
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.