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  • Is Stenting as “a Bridge to...
    Sabbagh, Charles; Browet, François; Diouf, Momar; Cosse, Cyril; Brehant, Olivier; Bartoli, Eric; Mauvais, François; Chauffert, Bruno; Dupas, Jean-Louis; Nguyen-Khac, Eric; Regimbeau, Jean-Marc

    Annals of surgery, 2013-July, 2013-Jul, 2013-07-00, 20130701, Letnik: 258, Številka: 1
    Journal Article

    OBJECTIVE AND BACKGROUND:Self-expanding metallic stent (SEMS) insertion has been suggested as a promising alternative to emergency surgery for left-sided malignant colonic obstruction (LMCO). However, the literature on the long-term impact of SEMS as “a bridge to surgery” is limited and contradictory. METHODS:From January 1998 to June 2011, we retrospectively identified patients operated on for LMCO with curative intent. The primary outcome criterion was overall survival. Short-term secondary endpoints included the technical success rate and overall success rate and long-term secondary endpoints included 5-year overall survival, 5-year cancer-specific mortality, 5-year disease-free survival, the recurrence rate, and mean time to recurrence. Patients treated with SEMS were analyzed on an intention-to-treat basis. Overall survival was analyzed after using a propensity score to correct for selection bias. RESULTS:There were 48 patients in the SEMS group and 39 in the surgery-only group. In the overall population, overall survival (P = 0.001) and 5-year overall survival (P = 0.0003) were significantly lower in the SEMS group than in the surgery-only group, and 5-year cancer-specific mortality was significantly higher in the SEMS group (48% vs 21%, respectively (P = 0.02)). Five-year disease-free survival, the recurrence rate, and the mean time to recurrence were better in the surgery-only group (not significant). For patients with no metastases or perforations at hospital admission, overall survival (P = 0.003) and 5-year overall survival (30% vs 67%, respectively, P = 0.001) were significantly lower in the SEMS group than in the surgery-only group. CONCLUSIONS:Our study results suggest worse overall survival of patients with LMCO with SEMS insertion compared with immediate surgery.