Abstract Background Peripartum cardiomyopathy (PPCM) is a heterogeneous condition characterized by heart failure and left ventricular dysfunction (LVEF<45%) in the absence of an alternative cause and a previous diagnosis of cardiomyopathy. The Aboriginal population (Inuit, First Nations, Metis) of Canada often has barriers to healthcare, which can lead to delays in diagnosis and treatment. Our objectives are to describe PPCM in a Canadian population, and to determine if Canadian Aboriginal women have worse clinical outcomes than non-Aboriginal women. Methods A retrospective study was performed at a single tertiary care center, between 2008-2014. Demographics, symptoms of presentation, medical history, discharge medications, blood work, echocardiographic parameters and follow up information were collected. Results A total of 177 women were screened, and 23 were included in the study (52% were Aboriginal). Aboriginal women were found to have higher rates of gravidity and parity, and higher incidence of tobacco smoking than non-Aboriginal women, and were more likely to be discharged on diuretics. At diagnosis, Aboriginal women were more likely to have a lower LVEF (20% (IQR 15-23%) vs 40% (IQR 30-42%), p=0.02) and a more dilated LV (LVEDD 64mm (IQR 57-74mm) vs 54mm (IQR 50-57mm), p<0.01). Recovery rate, defined as LVEF>50%, was similar (46% in Aboriginal patients and 60% in non-Aboriginal patients). Conclusion Our findings support that Aboriginal women with PPCM are more likely to present with lower LVEF and a more dilated LV, as well, require more symptomatic management. This is the first description and contrast of PPCM between Aboriginal and non-Aboriginal Canadians.