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Wehbe, Mohamed; Leung, Ada W. Y; Abrams, Michael J; Orvig, Chris; Bally, Marcel B
Dalton transactions : an international journal of inorganic chemistry, 08/2017, Letnik: 46, Številka: 33Journal Article
Although copper-ligand complexes appear to be promising as a new class of therapeutics, other than the family of copper( ii ) coordination compounds referred to as casiopeínas these compounds have yet to reach the clinic for human use. The pharmaceutical challenges associated with developing copper-based therapeutics will be presented in this article along with a discussion of the potential for high-throughput chemistry, computer-aided drug design, and nanotechnology to address the development of this important class of drug candidates. Copper complexes could define a promising new class of therapeutics, provided that there is a suitable way in which to formulate them for pharmaceutical use.
