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Aono, Hitomi; Choudhury, Mohammed Emamussalehin; Higaki, Hiromi; Miyanishi, Kazuya; Kigami, Yuka; Fujita, Kohdai; Akiyama, Jun‐ichi; Takahashi, Hisaaki; Yano, Hajime; Kubo, Madoka; Nishikawa, Noriko; Nomoto, Masahiro; Tanaka, Junya
Glia, November 2017, Letnik: 65, Številka: 11Journal Article
Parkinson's disease (PD) symptoms do not become apparent until most dopaminergic neurons in the substantia nigra pars compacta (SNc) degenerate, suggesting that compensatory mechanisms play a role. Here, we investigated the compensatory involvement of activated microglia in the SN pars reticulata (SNr) and the globus pallidus (GP) in a 6‐hydroxydopamine‐induced rat hemiparkinsonism model. Activated microglia accumulated more markedly in the SNr than in the SNc in the model. The cells had enlarged somata and expressed phagocytic markers CD68 and NG2 proteoglycan in a limited region of the SNr, where synapsin I‐ and postsynaptic density 95‐immunoreactivities were reduced. The activated microglia engulfed pre‐ and post‐synaptic elements, including NMDA receptors into their phagosomes. Cells in the SNr and GP engulfed red fluorescent DiI that was injected into the subthalamic nucleus (STN) as an anterograde tracer. Rat primary microglia increased their phagocytic activities in response to glutamate, with increased expression of mRNA encoding phagocytosis‐related factors. The synthetic glucocorticoid dexamethasone overcame the stimulating effect of glutamate. Subcutaneous single administration of dexamethasone to the PD model rats suppressed microglial activation in the SNr, resulting in aggravated motor dysfunctions, while expression of mRNA encoding glutamatergic, but not GABAergic, synaptic elements increased. These findings suggest that microglia in the SNr and GP become activated and selectively eliminate glutamatergic synapses from the STN in response to increased glutamatergic activity. Thus, microglia may be involved in a negative feedback loop in the indirect pathway of the basal ganglia to compensate for the loss of dopaminergic neurons in PD brains. Main Points Microglia eliminate glutamatergic synapses from the subthalamic nuclei in basal ganglia outputs in a rat parkinsonism model. By eliminating synapses, microglia give negative feedback compensating for dopaminergic neuron loss.
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