Background The current study examines interrelationships between social vulnerability, individual stressors, social and psychological resources, and depressive symptomatology among US adults during the current coronavirus disease 2019 (COVID‐19) pandemic. Methods Using an online survey platform, a poststratified (by age, gender, race, income, and geography), representative sample (n = 10,368 adults) is used in the analysis. Results On average, sample respondents report Center for Epidemiological Studies Depression (CES‐D) Scale symptomatology nearly a point higher than the often used cutoff score for clinical caseness (16+); one‐third of respondents had CES‐D scores higher than 25. Multiple regression results show elevated levels of depressive symptomatology among the socially vulnerable (women, Hispanic, unmarried, not working). Those persons expressing heightened COVID‐19 fear and moderate to high levels of food insecurity report more depressive symptoms than persons with less fear and low or no food insecurity. All three of the resource variables (mastery of fate, strength of ties, and optimism) are significant and in the negative direction. Conclusions In a snapshot, the data provide an important point prevalence assessment of adult depressive symptoms during the current public health crisis. Results highlight the significance of vulnerability and individual stressors in the wake of the COVID‐19 pandemic. In addition, the analysis affirms the importance of access to social and psychological resources to combat heightened fear and anxiety that persons report during the current pandemic.