To evaluate the impact of the series 13Reasons Why on depression and suicidal behaviors in children and adolescents. Data from the 2016 to 2018 Nationwide Inpatient Sample (NIS) and the Nationwide Emergency Department Sample (NEDS) of the Healthcare Cost and Utilization Project (HCUP) from 2016 to 2018 was used to determine the presentation in both settings for depression and suicidal thoughts and behavior. This was compared to predictive modeling for presentations in the same time frame. Following the release of 13 Reasons Why both hospital admissions and presentations to the Emergency Department (ED) increased for complaints of worsening depression or suicidal thoughts and behavior. This was more pronounced for youth aged 10–17 years, Black race, and female sex. There were no significant findings, overall, for females 6–9 years, but in-patient visits for depression increased in May 2017 for Black females 6–9 years. Males 6–9 years had higher rates of ED visits for depression and both ED and in-patient visits for suicidal behaviors. Secondary data analyses have known limitations including inability to track over time, inclusion of only visit-level data, and failure to collect variables of interest. The series 13 Reasons Why was likely associated with exacerbations of both depressive illnesses and suicidal behavior in youth, particularly for female and Black youth from 10 to 17 years. This study adds to known concerns regarding the role of media in influencing suicidal behavioral in vulnerable children and has important implications for youth monitoring and parent and youth education. More research is needed to identify specific targets for prevention. •Previous studies looked at suicide completions but did not examine emergency department or in-patient hospital visits for depression and suicidal behaviors.•Previous studies have included single hospital studies.•Previous studies have not included children 6–9 years of age.•Previous studies have not looked at race/ethnicity.