Purpose Gallstones are common in bariatric patients due to obesity and rapid weight loss. Bile duct stones after Roux-en-Y gastric bypass (RYGB) pose a technical challenge. We present our experience in management of bile duct stones following RYGB using laparoscopic-assisted endoscopic retrograde cholangiopancreatography (LA-ERCP). Materials and Methods Retrospective review of RYGB patients who had endoscopic intervention for bile duct stones between 2010 and 2019. We assessed demographic and clinical outcomes. Results There were 12 patients: 9 females, median age 64 years (range 34–73), median ASA score 3 (range 2–3), and median body mass index (BMI) 30 kg/m 2 (range 24.4–46). Median time of presentation since RYGB was 5 years (range 6–96 months). Clinical presentations were biliary pain with deranged liver function tests ( n  = 8, 67%) and cholangitis ( n  = 4, 33%). Ten patients (83%) had cholecystectomy prior to presentation. LA-ERCP was performed in all 12 patients. It was successful in 10 patients (83%) of which 7 were performed as a primary intervention for bile duct stones and 3 were for residual stones following previous bile duct exploration. Two out of 12 LA-ERCPs (17%) were converted to open duct clearance. Median overall hospital stay was 2.5 days (range 1–10). One patient developed post-ERCP pancreatitis; one had chronic pain. There was no major complication or mortality. Conclusion LA-ERCP is feasible for bile duct stones after RYGB and can clear the duct primarily or following previous surgical exploration. It also provides an opportunity to perform cholecystectomy and diagnostic laparoscopy .