Calcium peroxide (CaO2) has been proven to oxidize various organic pollutants when they exist as a single class of compounds. However, there is a lack of research on the potential of unactivated CaO2 to treat mixed chlorinated organic pollutants in soils. This study examined the potential of CaO2 in treating soils co-contaminated with p-dichlorobenzene (p-DCB) and p-chloromethane cresol (PCMC). The effects of CaO2 dosage and treatment duration on the rate of degradation were investigated. Furthermore, the collateral effects of the treatment on treated soil characteristics were studied. The result showed that unactivated CaO2 could oxidize mixed chlorinated organic compounds in wet soils. More than 69% of the pollutants in the wet soil were mineralized following 21 days of treatment with 3% (w/w) CaO2. The hydroxyl radicals played a significant role in the degradation process among the other decomposition products of hydrogen peroxide. Following the oxidation process, the treated soil pH was increased due to the formation of calcium hydroxide. Soil organic matter, cation exchange capacity, soil organic carbon, total nitrogen, and certain soil enzyme activities of the treated soil were decreased. However, the collateral effects of the system on electrical conductivity, available phosphorus, and particle size distribution of the treated soil were not significant. Likewise, since no significant release of heavy metals was seen in the treated soil matrix, the likelihood of metal ions as co-pollutants after treatment was low. Therefore, CaO2 can be a better alternative for treating industrial sites co-contaminated with chlorinated organic compounds. Display omitted •CaO2, 3% (w/w), degraded 69.26% of the pollutants in 21 days.•CaO2 oxidized components of the mixed pollutant at different rates.•OH was responsible species for the degradation of the pollutants.•Destruction of SOM is a significant challenge for the utilization of solid CaO2.•The likelihood of metal ions as co-contaminants after treatment is lower.