E-viri
Recenzirano
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González-Bello, Yelitza; Garcia-Valladares, Ignacio; Reyes-Pérez, Itzel Viridiana; García-Cerda, Daniel; Medrano-Ramírez, Gabriel; Navarro-Zarza, José E; Andrade-Ortega, Lilia; Maradiaga-Ceceña, Marco; Cardenas-Anaya, Alicia; Nava-Zavala, Arnulfo H; Orozco-Barocio, Gerardo; Vázquez-Del Mercado, Mónica; Rojo-Mejia, Armando; Loyo, Esthela; Gottschalk, Paola; Iglesias-Gamarra, Antonio; Vega, Kelly; Rojas, Cilia; Mantilla, Rubén; Gómez, Graciela; García-Kutzbach, Abraham; Fritzler, Marvin J; García-De La Torre, Ignacio
Journal of clinical rheumatology, 12/2021, Letnik: 27, Številka: 8Journal Article
BACKGROUNDDermatomyositis (DM) and polymyositis (PM) are forms of idiopathic inflammatory myopathies (IIMs), which are associated with the production of autoantibodies that are useful in the diagnosis and prognosis of the disease. OBJECTIVEThe aim of this study was to determine the frequency of antinuclear autoantibodies (ANAs), myositis-specific autoantibodies (MSAs), and myositis-associated autoantibodies (MAAs) in 6 Latin American countries. METHODSTwo hundred ten patients with IIM were included in this cross-sectional study from 2014 to 2017112 from Mexico, 46 from Colombia, 20 from Peru, 16 from the Dominican Republic, 10 from Argentina, and 6 from Guatemala. Antinuclear autoantibodies were detected by indirect immunofluorescence on HEp-2 cells. MSAs and MAAs were tested by a line immunoassay method. Mann-Whitney U and χ tests were used for statistical analysis. RESULTSOf the 210 IIM patients, 139 (66.2%) had DM, 59 (28%) PM, and 12 (5.7%) juvenile DM. The mean age was 43.5 (6–79 years); 158 (75.2%) were female, and 52 (24.8%) were male. The overall frequency of ANA was 60%. The most frequent patterns were fine speckled (AC-4) (78.3%) and cytoplasmic (AC-19) (6.45%). The most frequent MSA were anti–Mi-2 (38.5%) and anti–Jo-1 (11.9%). Anti–Mi-2 was more frequent in patients from Colombia (40.1%). The MAA more frequent were anti–Ro-52/TRIM21 (17.6%) and anti–PM-Scl75 (7.5%). CONCLUSIONSThis is the first study of ANA, MSA, and MAA in patients from 6 countries from the Panamerican League against Rheumatism myositis study group. We observed a general prevalence of 60% of ANA. In relation to MSA and MAA, anti–Mi-2 was the more frequent (38.5%).
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Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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