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Philippens, Ingrid H C H M; Böszörményi, Kinga P; Wubben, Jacqueline A M; Fagrouch, Zahra C; van Driel, Nikki; Mayenburg, Amber Q; Lozovagia, Diana; Roos, Eva; Schurink, Bernadette; Bugiani, Marianna; Bontrop, Ronald E; Middeldorp, Jinte; Bogers, Willy M; de Geus-Oei, Lioe-Fee; Langermans, Jan A M; Verschoor, Ernst J; Stammes, Marieke A; Verstrepen, Babs E
Viruses, 04/2022, Letnik: 14, Številka: 4Journal Article
SARS-CoV-2 causes acute respiratory disease, but many patients also experience neurological complications. Neuropathological changes with pronounced neuroinflammation have been described in individuals after lethal COVID-19, as well as in the CSF of hospitalized patients with neurological complications. To assess whether neuropathological changes can occur after a SARS-CoV-2 infection, leading to mild-to-moderate disease, we investigated the brains of four rhesus and four cynomolgus macaques after pulmonary disease and without overt clinical symptoms. Postmortem analysis demonstrated the infiltration of T-cells and activated microglia in the parenchyma of all infected animals, even in the absence of viral antigen or RNA. Moreover, intracellular α-synuclein aggregates were found in the brains of both macaque species. The heterogeneity of these manifestations in the brains indicates the virus' neuropathological potential and should be considered a warning for long-term health risks, following SARS-CoV-2 infection.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Vir: Osebne bibliografije
in: SICRIS
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