Background: Adolescence in mammals is a period marked by increased novelty-seeking and enhanced responsiveness to the stressful properties of novel stimuli. Despite the need to taste potentially toxic novel foods during the adolescent growth spurt, there has been little study of taste neophobia and its attenuation. Method: Four experiments were carried out to compare taste neophobia and related memory processes in male and female adolescent (PND28) and adult (PND70) Wistar rats. Experiments 1 and 2 evaluated attenuation of taste neophobia to cider vinegar (3%) and sodium saccharin (0.1%) solutions were evaluated. Additionally, to test the role of memory in neophobia during adolescence, latent inhibition of taste aversion and object recognition memory were assessed in Experiment 3 and Experiment 4, respectively. Results: Adolescent and adult rats exhibited taste neophobia to the saccharin solution but adolescent rats required more exposure trials than adults to recognize the vinegar solution as safe. Both groups exhibited similar latent inhibition of taste aversion and object recognition memory. No sex effect was significant. Conclusions: Contrary to the accepted view associating adolescence with reduced neophobia, adolescent rats exhibited taste neophobia which even increased when sour tastes were encountered. Keywords: Adolescence Attenuation of neophobia Flavor Recognition memory Rat Antecedentes: La adolescencia esta marcada por busqueda de la novedad y acentuada sensibilidad a las propiedades estresantes de los estimulos novedosos. A pesar de la necesidad de probar nuevos alimentos potencialmente toxicos durante el periodo de crecimiento adolescente, la neofobia gustativa y su atenuacion durante este periodo apenas ha sido estudiada. Metodo: Se evaluaron la neofobia gustativa y los procesos de memoria relacionados en ratas Wistar macho y hembra adolescentes (PND28) y adultas (PND70). En los Experimentos 1 y 2 Se exploro la atenuacion de la neofobia gustativa a soluciones de vinagre de sidra (3%) y sacarina sodica (0,1%), respectivamente. En los experimentos 3 y 4, se evaluo tambien la inhibicion latente de aversiones gustativas y la memoria de reconocimiento de objetos. Resultados: Adolescentes y adultos mostraron neofobia gustativa a la sacarina, pero las ratas adolescentes requirieron mas exposiciones a la solucion de vinagre para reconocerla como segura. No hubo diferencias entre los grupos en los Experimentos 3 and 4. No se hallaron efectos significativos del sexo. Conclusiones: A pesar de la ampliamente aceptada asociacion entre adolescencia y reducida neofobia, las ratas adolescentes muestran neofobia al sabor que resulta incluso incrementada cuando se trata de sabores acidos. Palabras clave: Adolescencia Atenuacion de la neofobia Sabor Memoria de reconocimiento Rata