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Lim, Sean H; Stuart, Beth; Joseph-Pietras, Debora; Johnson, Marina; Campbell, Nicola; Kelly, Adam; Jeffrey, Danielle; Turaj, Anna H; Rolfvondenbaumen, Kate; Galloway, Celine; Wynn, Thomas; Coleman, Adam R; Ward, Benjamin; Long, Karen; Coleman, Helen; Mundy, Carina; Bates, Andrew T; Ayres, Diana; Lown, Robert; Falconer, Janlyn; Brake, Oliver; Batchelor, James; Willimott, Victoria; Bowzyk Al-Naeeb, Anna; Robinson, Lisa; O'Callaghan, Ann; Collins, Graham P; Menne, Tobias; Faust, Saul N; Fox, Christopher P; Ahearne, Matthew; Johnson, Peter W M; Davies, Andrew J; Goldblatt, David
Nature cancer, 05/2022, Letnik: 3, Številka: 5Journal Article
Patients with hematological malignancies are at increased risk of severe COVID-19 outcomes due to compromised immune responses, but the insights of these studies have been compromised due to intrinsic limitations in study design. Here we present the PROSECO prospective observational study ( NCT04858568 ) on 457 patients with lymphoma that received two or three COVID-19 vaccine doses. We show undetectable humoral responses following two vaccine doses in 52% of patients undergoing active anticancer treatment. Moreover, 60% of patients on anti-CD20 therapy had undetectable antibodies following full vaccination within 12 months of receiving their anticancer therapy. However, 70% of individuals with indolent B-cell lymphoma displayed improved antibody responses following booster vaccination. Notably, 63% of all patients displayed antigen-specific T-cell responses, which increased after a third dose irrespective of their cancer treatment status. Our results emphasize the urgency of careful monitoring of COVID-19-specific immune responses to guide vaccination schemes in these vulnerable populations.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Vir: Osebne bibliografije
in: SICRIS
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