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Pelizaro, Bruno I; Batista, Jaqueline C Z; Portapilla, Gisele B; das Neves, Amarith R; Silva, Fernanda; Carvalho, Diego B; Shiguemoto, Cristiane Y K; Pessatto, Lucas R; Paredes-Gamero, Edgar J; Cardoso, Iara A; Luccas, Pedro H; Nonato, M Cristina; Lopes, Norberto P; Galvão, Fernanda; Oliveira, Kelly M P; Cassemiro, Nadla S; Silva, Denise B; Piranda, Eliane M; Arruda, Carla C P; de Albuquerque, Sergio; Baroni, Adriano C M
Journal of medicinal chemistry, 2024-Feb-22, 2024-02-22, Letnik: 67, Številka: 4Journal Article
A series of 28 compounds, 3-nitro-1 -1,2,4-triazole, were synthesized by click-chemistry with diverse substitution patterns using medicinal chemistry approaches, such as bioisosterism, Craig-plot, and the Topliss set with excellent yields. Overall, the analogs demonstrated relevant in vitro antitrypanosomatid activity. Analog (R = 4-OCF -Ph, IC = 0.09 μM, SI = >555.5) exhibited an outstanding antichagasic activity ( , Tulahuen LacZ strain) 68-fold more active than benznidazole (BZN, IC = 6.15 μM, SI = >8.13) with relevant selectivity index, and suitable LipE = 5.31. was considered an appropriate substrate for the type I nitro reductases (TcNTR I), contributing to a likely potential mechanism of action for antichagasic activity. Finally, showed nonmutagenic potential against strains (TA98, TA100, and TA102). Therefore, 3-nitro-1 -1,2,4-triazole is a promising antitrypanosomatid candidate for in vivo studies.
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