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Mibu, Nobuko; Yokomizo, Kazumi; Aki, Hatsumi; Ota, Norimasa; Fujii, Hiroyuki; Yuzuriha, Ai; Saneyoshi, Shiori; Tanaka, Aoi; Koga, Airi; Zhou, Jianrong; Miyata, Takeshi; Sumoto, Kunihiro
Chemical & pharmaceutical bulletin, 11/2015, Letnik: 63, Številka: 11Journal Article
As one of our projects, we here report some new molecular modifications of 2,4,6-trichloro-1,3,5-triazine (TCTAZ: 1) to symmetrical 2,4,6-trialkoxy- or 2,4,6-triaryloxy-substituted 1,3,5-triazine (TAZ) molecules, as well as the results of anti-herpes simplex virus type 1 (anti-HSV-1) activity evaluation of synthesized 2,4,6-trisubstituted TAZ derivatives. Among the tested 2,4,6-trisubstituted TAZ derivatives, we reconfirmed that a C3-symmetrical TAZ derivative, 4e, shows the highest level of anti-HSV-1 activity with a good selectivity index. In this paper, we also report the results of the preparation of newly targeted TAZ derivatives and the structure–activity relationships (SARs) of these trialkoxy-substituted TAZ derivatives and related compounds. The sugar recognition properties of C3-symmetrical TAZ derivative 4e are also described.
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in: SICRIS
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