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Chung, Kuei-Pin; Cheng, Chih-Ning; Chen, Yi-Jung; Hsu, Chia-Lang; Huang, Yen-Lin; Hsieh, Min-Shu; Kuo, Han-Chun; Lin, Ya-Ting; Juan, Yi-Hsiu; Nakahira, Kiichi; Chen, Yen-Fu; Liu, Wei-Lun; Ruan, Sheng-Yuan; Chien, Jung-Yien; Plataki, Maria; Cloonan, Suzanne M; Carmeliet, Peter; Choi, Augustine M. K; Kuo, Ching-Hua; Yu, Chong-Jen
Nature communications, 08/2024, Letnik: 15, Številka: 1Journal Article
Type 2 alveolar epithelial (AT2) cells of the lung are fundamental in regulating alveolar inflammation in response to injury. Impaired mitochondrial long-chain fatty acid β-oxidation (mtLCFAO) in AT2 cells is assumed to aggravate alveolar inflammation in acute lung injury (ALI), yet the importance of mtLCFAO to AT2 cell function needs to be defined. Here we show that expression of carnitine palmitoyltransferase 1a (CPT1a), a mtLCFAO rate limiting enzyme, in AT2 cells is significantly decreased in acute respiratory distress syndrome (ARDS). In mice, Cpt1a deletion in AT2 cells impairs mtLCFAO without reducing ATP production and alters surfactant phospholipid abundance in the alveoli. Impairing mtLCFAO in AT2 cells via deleting either Cpt1a or Acadl (acyl-CoA dehydrogenase long chain) restricts alveolar inflammation in ALI by hindering the production of the neutrophilic chemokine CXCL2 from AT2 cells. This study thus highlights mtLCFAO as immunometabolism to injury in AT2 cells and suggests impaired mtLCFAO in AT2 cells as an anti-inflammatory response in ARDS.Impaired mitochondrial long-chain fatty acid β-oxidation (mtLCFAO) in type 2 alveolar epithelial (AT2) cells is thought to aggravate alveolar inflammation in acute lung injury. Here, the authors show that the mtLCFAO rate limiting enzyme CPT1a is decreased in AT2 cells in acute respiratory distress syndrome, highlighting the role of mtLCFAO in immunometabolism in this context.
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