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Ejim, Linda; Farha, Maya A; Falconer, Shannon B; Wildenhain, Jan; Coombes, Brian K; Tyers, Mike; Brown, Eric D; Wright, Gerard D
Nature chemical biology, 06/2011, Letnik: 7, Številka: 6Journal Article
Combinations of antibiotics are commonly used in medicine to broaden antimicrobial spectrum and generate synergistic effects. Alternatively, combination of nonantibiotic drugs with antibiotics offers an opportunity to sample a previously untapped expanse of bioactive chemical space. We screened a collection of drugs to identify compounds that augment the activity of the antibiotic minocycline. Unexpected synergistic drug combinations exhibited in vitro and in vivo activity against bacterial pathogens, including multidrug-resistant isolates.
