EC₅₀and EC₉₅(the effective concentrations to cause inhibitions by 50 and 95%, respectively) are commonly used to express fungicide potency. Different methods are currently employed to calculate EC₅₀and EC₉₅values. In this study, EC₅₀and EC₉₅values for fungicide epoxiconazole against 34 isolates of Sclerotinia sclerotiorum were calculated with seven different methods. Results showed that for both EC₅₀and EC₉₅calculations, there was no significant difference among three statistical programs IBM spss®, GraphPad Prism®and dps®(P ≥ 0.066). Methods linear log (linear regression of mycelial growth inhibition vs. logarithmic concentration) and interpolation log (linear interpolation from inhibition and logarithmic concentration data) were not significantly different (P ≥ 0.058) from IBM spss in EC₅₀calculations. These results indicate that among the seven methods, the three statistical programs IBM spss, GraphPad Prism, dps and linear log method are appropriate for EC₅₀calculations. But for EC₉₅calculations, only the three statistical programs are recommended, and GraphPad Prism is likely to give a little higher values than spss and dps.