Abstract Purpose This research is to determine scenarios and perspectives for improving the cluster strategy of business integration in the post-COVID-19 era with the help of the methodology of the game theory. Design/Methodology/Approach The methodology of this research includes the complex method, statistical method, correlation analysis and the game theory of decision-making. Findings Based on the analysis of scientific approaches, we formulate the authors' treatment of the essence of the notion of clustering, which characteristics are evaluated in this work. In this treatment, we distinguish factors that influence the development of clustering of business structures of the state, which level is assessed within the analysis. The components of the competitiveness of business structures are among such factors. Cluster structures of certain countries successfully functioned during the COVID-19 pandemic, using effective strategies created independently (United States) and based on the strategies of non-market regulation (China). Originality/Value The scientific novelty of this research consists in the identification of the types and characteristics of the strategies of clustering of business structures formed during the COVID-19 and post-COVID-19 eras.