The usage of enterprise social media (ESM) has rapidly increased in the workplace. Firms adopt the ESM platform for the knowledge sharing and work-related communication of employees. However, the efficient use of the ESM technology in the workplace remains a challenge for organizations and business leaders. Previous studies have inconsiderably focused on this domain of research. The existing research investigates the influence of ESM usage on employee agility through meta-knowledge considering the moderation role of digital fluency. Using 263 responses from Chinese employees, this study investigates how ESM usage improves employee agility through meta-knowledge. Results confirm that organizations can improve the meta-knowledge of employees through investment in the ESM technology and that ESM usage is significantly related to individual agility via meta-knowledge. Digital fluency strengthens the relationship between ESM usage and employee agility and supports the correlation between ESM usage and employee agility via meta-knowledge. Finally, on the basis of the results, the theoretical and managerial implications of the study are discussed.