To find out the anthropometric relationship of Inter-condylar distance to Inter-canine and Inter-molar distance of maxillary arch and occlusal vertical dimension in dentate individuals of South Indian population. A total number of 120 dentate individuals were randomly equally divided into Group A and Group B. According to the face form, each Group was again subdivided into four subgroups. Subgroup A1 and B1 contained Square face form, Subgroup A2 and B2 Tapered, Subgroup A3 and B3 Square tapered and Subgroup A4 and B4 Ovoid face form. The ratio of ICD to U3, U6 and OVD of Group A individuals were applied to the Group B individuals with similar face forms and the clinical significance of the ratios were evaluated. No significant difference (p-value=0.841) was observed in the ratio of U6 to ICD (U6/ICD) in all the face forms. A significant difference (p-value = 0.010) in the mean value was observed when the ratio of OVD to ICD (OVD/ICD) was compared between the squared tapered face form of Group A (0.60 ± 0.01) and Group B (0.06±0.03). A significant difference (p value = 0.007) was observed between the measured (62.47 ±2.77) and calculated (64.99±2.61) values of OVD in square taper face form. In south Indian population, ICD can be used as a reliable guide line to determine the bucco-palatal position of maxillary first molar irrespective of the face forms.