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  • Spherical Nucleic Acids
    Cutler, Joshua I; Auyeung, Evelyn; Mirkin, Chad A

    Journal of the American Chemical Society, 01/2012, Letnik: 134, Številka: 3
    Journal Article

    A historical perspective of the development of spherical nucleic acid (SNA) conjugates and other three-dimensional nucleic acid nanostructures is provided. This Perspective details the synthetic methods for preparing them, followed by a discussion of their unique properties and theoretical and experimental models for understanding them. Important examples of technological advances made possible by their fundamental properties spanning the fields of chemistry, molecular diagnostics, gene regulation, medicine, and materials science are also presented.