E-viri
Recenzirano
-
Clark, Michael P; Ledeboer, Mark W; Davies, Ioana; Byrn, Randal A; Jones, Steven M; Perola, Emanuele; Tsai, Alice; Jacobs, Marc; Nti-Addae, Kwame; Bandarage, Upul K; Boyd, Michael J; Bethiel, Randy S; Court, John J; Deng, Hongbo; Duffy, John P; Dorsch, Warren A; Farmer, Luc J; Gao, Huai; Gu, Wenxin; Jackson, Katrina; Jacobs, Dylan H; Kennedy, Joseph M; Ledford, Brian; Liang, Jianglin; Maltais, François; Murcko, Mark; Wang, Tiansheng; Wannamaker, M. Woods; Bennett, Hamilton B; Leeman, Joshua R; McNeil, Colleen; Taylor, William P; Memmott, Christine; Jiang, Min; Rijnbrand, Rene; Bral, Christopher; Germann, Ursula; Nezami, Azin; Zhang, Yuegang; Salituro, Francesco G; Bennani, Youssef L; Charifson, Paul S
Journal of medicinal chemistry, 08/2014, Letnik: 57, Številka: 15Journal Article
In our effort to develop agents for the treatment of influenza, a phenotypic screening approach utilizing a cell protection assay identified a series of azaindole based inhibitors of the cap-snatching function of the PB2 subunit of the influenza A viral polymerase complex. Using a bDNA viral replication assay ( Wagaman P. C. ; Leong M. A. ; Simmen K. A. Development of a novel influenza A antiviral assay. J. Virol. Methods 2002, 105, 105−114 ) in cells as a direct measure of antiviral activity, we discovered a set of cyclohexyl carboxylic acid analogues, highlighted by VX-787 (2). Compound 2 shows strong potency versus multiple influenza A strains, including pandemic 2009 H1N1 and avian H5N1 flu strains, and shows an efficacy profile in a mouse influenza model even when treatment was administered 48 h after infection. Compound 2 represents a first-in-class, orally bioavailable, novel compound that offers potential for the treatment of both pandemic and seasonal influenza and has a distinct advantage over the current standard of care treatments including potency, efficacy, and extended treatment window.
Avtor
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.