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Kawai, Tatsuo; Cosimi, A. Benedict; Spitzer, Thomas R; Tolkoff-Rubin, Nina; Suthanthiran, Manikkam; Saidman, Susan L; Shaffer, Juanita; Preffer, Frederic I; Ding, Ruchuang; Sharma, Vijay; Fishman, Jay A; Dey, Bimalangshu; Ko, Dicken S.C; Hertl, Martin; Goes, Nelson B; Wong, Waichi; Williams, Winfred W; Colvin, Robert B; Sykes, Megan; Sachs, David H
New England journal of medicine/The New England journal of medicine, 01/2008, Letnik: 358, Številka: 4Journal Article
Five patients with end-stage renal disease received bone marrow and kidney transplants from HLA-mismatched living related donors. Transient hematopoietic chimerism developed in all five. In one patient, irreversible humoral rejection occurred. In the other four recipients, immunosuppressive therapy was discontinued after 9 to 14 months and renal function has subsequently remained stable. Five patients with end-stage renal disease received bone marrow and kidney transplants from HLA-mismatched living related donors. In four recipients, immunosuppressive therapy was discontinued after 9 to 14 months and renal function has subsequently remained stable. Long-term results of organ transplantation remain unsatisfactory, mainly because of chronic rejection and complications associated with immunosuppressive medications. 1 , 2 Immune tolerance, which has been achieved in animal models, might provide a means for avoiding both of these problems. However, the results of attempts to extend such studies from laboratory animals to humans have been disappointing. 3 – 7 Tolerance of allografts has been induced in mice 8 and larger animals 9 by first transplanting hematopoietic stem cells from the prospective donor into the recipient, thereby creating a lymphohematopoietic chimera in which donor and recipient hematopoiesis coexist (“mixed chimera”). Using a nonmyeloablative perioperative regimen, we . . .
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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