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De Leon-Oliva, Diego; Garcia-Montero, Cielo; Fraile-Martinez, Oscar; Boaru, Diego Liviu; García-Puente, Luis; Rios-Parra, Antonio; Garrido-Gil, Maria J; Casanova-Martín, Carlos; García-Honduvilla, Natalio; Bujan, Julia; Guijarro, Luis G; Alvarez-Mon, Melchor; Ortega, Miguel A
Biology, 05/2023, Letnik: 12, Številka: 5Journal Article
Macrophages are a type of immune cell distributed throughout all tissues of an organism. Allograft inflammatory factor 1 (AIF1) is a calcium-binding protein linked to the activation of macrophages. AIF1 is a key intracellular signaling molecule that participates in phagocytosis, membrane ruffling and F-actin polymerization. Moreover, it has several cell type-specific functions. AIF1 plays important roles in the development of several diseases: kidney disease, rheumatoid arthritis, cancer, cardiovascular diseases, metabolic diseases and neurological disorders, and in transplants. In this review, we present a comprehensive review of the known structure, functions and role of AIF1 in inflammatory diseases.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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