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Xiao, Zong‐Yu; Liu, Yan; Sun, Yan‐Ping; Liu, Yuan; Yang, Bing‐You; Kuang, Hai‐Xue
Chemistry & biodiversity, March 2020, 2020-Mar, 2020-03-00, 20200301, Letnik: 17, Številka: 3Journal Article
A new isoalloxazine alkaloid, named bupleurine A (1), along with five known compounds (2–6), were isolated from the aerial parts of Bupleurum chinense DC. The structure elucidation of the new alkaloid (1) was employed by combining NMR and HR‐MS data with comparison of reference in the literature. Five known compounds (2–6) were isolated from Bupleurum genus for the first time. Additionally, their antiproliferative activities on HeLa cells were evaluated by MTT assay and IC50 of compounds 1 and 4–6 were below 10 μm after treatment for 24 h.
