Shear wave splitting of SK(K)S phases is often used to examine upper mantle anisotropy. In specific cases, however, splitting of these phases may reflect anisotropy in the lowermost mantle. Here we present SKS and SKKS splitting measurements for 233 event‐station pairs at 34 seismic stations that sample D″ beneath Africa. Of these, 36 pairs show significantly different splitting between the two phases, which likely reflects a contribution from lowermost mantle anisotropy. The vast majority of discrepant pairs sample the boundary of the African large low shear velocity province (LLSVP), which dominates the lower mantle structure beneath this region. In general, we observe little or no splitting of phases that have passed through the LLSVP itself and significant splitting for phases that have sampled the boundary of the LLSVP. We infer that the D″ region just outside the LLSVP boundary is strongly deformed, while its interior remains undeformed (or weakly deformed). Key Points There is strong anisotropy just outside the boundary of the African LLSVP The interior of the African LLSVP is (nearly) isotropic The LLSVP may represent a barrier to ambient mantle flow