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Becker, Markus; Catana, Ciprian; Eichner, Martin; Röcken, Martin; Kneilling, Manfred; Judenhofer, Martin S; Klingel, Karin; Wehrl, Hans F; Widmaier, Stefan; Pichler, Bernd J; Thielscher, Axel; Uludag, Kamil; Newport, Danny F; Siegel, Stefan B; Claussen, Claus D; Machulla, Hans-Jürgen; Lichy, Matthias P; Nutt, Robert E; Cherry, Simon R; Reischl, Gerald
Nature medicine, 04/2008, Letnik: 14, Številka: 4Journal Article
Noninvasive imaging at the molecular level is an emerging field in biomedical research. This paper introduces a new technology synergizing two leading imaging methodologies: positron emission tomography (PET) and magnetic resonance imaging (MRI). Although the value of PET lies in its high-sensitivity tracking of biomarkers in vivo, it lacks resolving morphology. MRI has lower sensitivity, but produces high soft-tissue contrast and provides spectroscopic information and functional MRI (fMRI). We have developed a three-dimensional animal PET scanner that is built into a 7-T MRI. Our evaluations show that both modalities preserve their functionality, even when operated isochronously. With this combined imaging system, we simultaneously acquired functional and morphological PET-MRI data from living mice. PET-MRI provides a powerful tool for studying biology and pathology in preclinical research and has great potential for clinical applications. Combining fMRI and spectroscopy with PET paves the way for a new perspective in molecular imaging.
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Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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