E-viri
Recenzirano
Odprti dostop
-
Ataman, Bulent; Boulting, Gabriella L; Harmin, David A; Yang, Marty G; Baker-Salisbury, Mollie; Yap, Ee-Lynn; Malik, Athar N; Mei, Kevin; Rubin, Alex A; Spiegel, Ivo; Durresi, Ershela; Sharma, Nikhil; Hu, Linda S; Pletikos, Mihovil; Griffith, Eric C; Partlow, Jennifer N; Stevens, Christine R; Adli, Mazhar; Chahrour, Maria; Sestan, Nenad; Walsh, Christopher A; Berezovskii, Vladimir K; Livingstone, Margaret S; Greenberg, Michael E
Nature (London), 11/2016, Letnik: 539, Številka: 7628Journal Article
Sensory stimuli drive the maturation and function of the mammalian nervous system in part through the activation of gene expression networks that regulate synapse development and plasticity. These networks have primarily been studied in mice, and it is not known whether there are species- or clade-specific activity-regulated genes that control features of brain development and function. Here we use transcriptional profiling of human fetal brain cultures to identify an activity-dependent secreted factor, Osteocrin (OSTN), that is induced by membrane depolarization of human but not mouse neurons. We find that OSTN has been repurposed in primates through the evolutionary acquisition of DNA regulatory elements that bind the activity-regulated transcription factor MEF2. In addition, we demonstrate that OSTN is expressed in primate neocortex and restricts activity-dependent dendritic growth in human neurons. These findings suggest that, in response to sensory input, OSTN regulates features of neuronal structure and function that are unique to primates.
Avtor
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.