With the advancement of medical and digital technologies, smart skin adhesive patches have emerged as a key player for complex medical purposes. In particular, skin adhesive patches with integrated electronics have created an excellent platform for monitoring health conditions and intelligent medication. However, the efficient design of the adhesive patches is still challenging as it requires a strong combination of network structure, adhesion, physical properties, and biocompatibility. To design an assimilated device, one must have a deep knowledge of various skin adhesive patches. This article provides a comprehensive review of the recent advances in skin‐adhesive patches, including hydrogel‐based adhesive patches, transdermal patches, and electronic skin (E‐skin) patches, for various biomedical applications such as wound healing, drug delivery, biosensing, and health monitoring. Furthermore, the key challenges, implementable strategies, and future designs that can potentially provide researchers in designing innovative multipurpose smart skin patches are discussed. These advanced approaches are promising for managing the health and fitness of patients who require regular medical care. While skin adhesive patches have emerged as a promising solution for transdermal theragnostic; the cutting‐edge design of skin patches is still challenging for translational applications. This review recapitulates the latest advances in skin‐adhesive patches, including hydrogel‐based adhesive patches, transdermal patches, and E‐skin patches that can help researchers to design innovative multipurpose skin patches.