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Skehel, John J; Wiley, Don C
Cell, 12/1998, Letnik: 95, Številka: 7Book Review, Journal Article
Recent structural studies of protein complexes involved in neurotransmitter release and intracellular vesicle trafficking reveal similarities with the structures of a group of virus membrane fusion proteins. In both cases hydrophobic sequences, embedded in the membranes to be fused, are located at the same end of a rod-shaped complex composed of a bundle of long alpha helices. This molecular arrangement is proposed to cause close membrane apposition as the complexes are assembled for membrane fusion.
