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Fujisaki, Fumiko; Toyofuku, Keiko; Egami, Mayu; Ishida, Shiori; Nakamoto, Naho; Kashige, Nobuhiro; Miake, Fumio; Sumoto, Kunihiro
Chemical & pharmaceutical bulletin, 10/2013, Letnik: 61, Številka: 10Journal Article
In connection with our studies on antibacterial compounds in the class of 5-dialkylaminomethylhydantoins against Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) strains, some molecular modifications were attempted. The antibacterial activities of all of the synthesized hydantoin derivatives were evaluated. Among the hydantoin derivatives designed in this study, C2-symmetrical twin-drug type compound (7) showed the highest level of antibacterial activity against S. aureus strain.
