People are attributing specific meanings to individual places (regions) by their activity and thus they are visualizing their life ideas. In this way genius loci (genius regionis) is developed in human consciousness. This social value of the landscape, generated by the generational accumulation of human experience, forms the central part of the potential of places and regions. It is well known that the activation of the socio-economic potential of the country, including genius loci (genius regionis), contributes even to the development of cross-border cooperation. An example may be the fact that (after more than one hundred years) a genius locus of the Eastern Front of the World War I has become the generator of the development of cross-border cooperation in the Slovak-Polish-Ukrainian region.