E-viri
Recenzirano
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Rivera, Carolina; Bacilio-Beltrán, Héctor A; Puebla-Pérez, Ana M; Rangel-Salas, Irma I; Alvarado-Rodríguez, José G; Flores-Moreno, Roberto; Velázquez-Juárez, Gilberto; Peregrina-Lucano, A. Aarón; Becerra-Martínez, Elvia; Valdez-Ruvalcaba, Jaime; Rubio, José E; Cortés-Llamas, Sara A
New journal of chemistry, 07/2022, Letnik: 46, Številka: 29Journal Article
The synthesis of cis and trans geometrical isomers of platinum( ii ) complexes with a symmetric N-heterocyclic carbene ligand ( Me NHC) is reported. These complexes were obtained from 1,3-dimethylimidazolium-2-carboxylate, a masked NHC precursor. Their cytotoxicity, oxidative nature, and antibacterial behavior were investigated. The highest cytotoxic effect (IC 50 = 1.21 μM) was observed with the cis -Pt( Me NHC) 2 Cl 2 complex in the cervix cancerous cell line HeLa. Cis - and trans -NHC-Pt( ii ) isomers from the masked carbene 1,3-dimethylimidazolium-2-carboxylate: the relevance of isomerism in the biological activity.
