E-viri
Recenzirano
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Xia, Yuqiong; Rao, Lang; Yao, Huimin; Wang, Zhongliang; Ning, Pengbo; Chen, Xiaoyuan
Advanced materials (Weinheim), 10/2020, Letnik: 32, Številka: 40Journal Article
Macrophages play an important role in cancer development and metastasis. Proinflammatory M1 macrophages can phagocytose tumor cells, while anti‐inflammatory M2 macrophages such as tumor‐associated macrophages (TAMs) promote tumor growth and invasion. Modulating the tumor immune microenvironment through engineering macrophages is efficacious in tumor therapy. M1 macrophages target cancerous cells and, therefore, can be used as drug carriers for tumor therapy. Herein, the strategies to engineer macrophages for cancer immunotherapy, such as inhibition of macrophage recruitment, depletion of TAMs, reprograming of TAMs, and blocking of the CD47‐SIRPα pathway, are discussed. Further, the recent advances in drug delivery using M1 macrophages, macrophage‐derived exosomes, and macrophage‐membrane‐coated nanoparticles are elaborated. Overall, there is still significant room for development in macrophage‐mediated immune modulation and macrophage‐mediated drug delivery, which will further enhance current tumor therapies against various malignant solid tumors, including drug‐resistant tumors and metastatic tumors. Macrophages play important roles in tumor growth and treatment. Strategies to engineer tumor‐associated macrophages (TAMs) to combat tumors are summarized as follows: inhibiting macrophage recruitment, depleting TAMs, reprograming TAMs, and blocking the CD47‐SIRPα pathway. Furthermore, tumor‐targeting M1 macrophages are used in anti‐cancer drug delivery in three ways: as macrophages, macrophage‐derived exosomes, and macrophage‐coated nanoparticles acting as drug carriers.
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Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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