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Wang, Sheng; Yu, Guocan; Wang, Zhantong; Jacobson, Orit; Lin, Li‐Sen; Yang, Weijing; Deng, Hongzhang; He, Zhimei; Liu, Yuan; Chen, Zhi‐Yi; Chen, Xiaoyuan
Angewandte Chemie International Edition, October 7, 2019, Letnik: 58, Številka: 41Journal Article
Reactive oxygen species (ROS) can be used not only as a therapeutic agent for chemodynamic therapy (CDT), but also as a stimulus to activate release of antitumor drugs, achieving enhanced efficacy through the combination of CDT and chemotherapy. Here we report a pH/ROS dual‐responsive nanomedicine consisting of β‐lapachone (Lap), a pH‐responsive polymer, and a ROS‐responsive polyprodrug. In the intracellular acidic environment, the nanomedicine can realize pH‐triggered disassembly. The released Lap can efficiently generate hydrogen peroxide, which will be further converted into highly toxic hydroxyl radicals via the Fenton reaction. Subsequently, through ROS‐induced cleavage of thioketal linker, doxorubicin is released from the polyprodrug. In vivo results indicate that the cascade of ROS generation and antitumor‐drug release can effectively inhibit tumor growth. This design of nanomedicine with cascade reactions offers a promising strategy to enhance antitumor efficacy. Cascade reactions: A nanomedicine that consists of a pH‐responsive polymer and polyprodrug, which is responsive to reactive oxygen species (ROS), has been developed. This nanomedicine can achieve enhanced antitumor efficacy by the cascade of ROS generation and drug release, which is promising for chemo/chemodynamic combination cancer therapy.
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Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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