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Ferguson, Sherise D.; Srinivasan, Visish M.; Heimberger, Amy B.
Journal of neuro-oncology, 07/2015, Letnik: 123, Številka: 3Journal Article
The role of tumor-induced immune modulation in cancer progression is currently a focus of investigation. The signal transducer and activator of transcription 3 (STAT3) is an established molecular hub of immunosuppression, and its signaling pathways are classically overactivated within malignancies. This article will review STAT3 operational mechanisms within the immune system and the tumor microenvironment, with a focus on therapeutic strategies that may impact outcomes for patients with cancer.
